曼彻斯特大学医学博士岗位

Metals and host-pathogen interactions: the role of metal handling systems in the human gastrointestinal pathogen Campylobacter jejuni

The University of Manchester-Faculty of Biology,Medicine and Health

About the Project

Campylobacter jejuni is a globally important food-borne pathogen causing an estimated 400-500 million cases of acute human gastroenteritis each year. This bacterium is able to colonize and persist in farm animals, particularly chickens, which are the major source of human campylobacteriosis. Metals (such as zinc and copper) play a central role in the outcome of bacteria-host interactions. To control infections, in a process termed nutritional immunity, the immune system exploits both the need for bacteria to acquire metals in order to proliferate and the innate toxicity of metals. In response pathogenic bacteria have evolved a myriad of metal-sensing, metal-acquisition and metal-detoxification systems which represent key virulence determinants. These systems offer attractive targets for the development of much needed novel antimicrobial agents as well as opportunities to exploit nutritional immunity. This project combines the expertise of two laboratories (Cavet-Metals in bacterial pathogens,Linton- Campylobacter biology) and focuses on uncovering and characterising the metal handling systems in C. jejuni, and examining their roles in allowing this pathogen to adapt to metal stresses within its human and animal hosts.  

Candidates are expected to hold (or be about to obtain) a minimum upper second class honours degree (or equivalent) in a related area / subject.  Candidates with experience in general molecular biology and bacteriology techniques are encouraged to apply. 

For international students we also offer a unique 4 year PhD programme that gives you the opportunity to undertake an accredited Teaching Certificate whilst carrying out an independent research project across a range of biological, medical and health sciences. 

Funding Notes

Applications are invited from self-funded students. This project has a Band 2 fee.  

Equality, diversity and inclusion is fundamental to the success of The University of Manchester, and is at the heart of all of our activities.

References

Barnawi, H., Masri, N., Hussain, N., Al-lawati, B., Mayasari, E., Gulbicka, A., Jervis, A. J., Huang, M., Cavet, J. S. & Linton, D., 2020, RNA-based thermoregulation of a Campylobacter jejuni zinc resistance determinant. In: PLoS Pathogens 16, e1009008.

电脑翻译：  

曼彻斯特大学生物、医学和健康学院  

关于这个项目  

空肠弯曲菌是一种全球重要的食源性病原体，每年造成约4-5亿例急性人类肠胃炎。这种细菌能够在农场动物中定居并持续存在，特别是鸡，鸡是人类弯曲杆菌病的主要来源。金属(如锌和铜)在细菌-宿主相互作用的结果中起着中心作用。为了控制感染，在一个被称为营养免疫的过程中，免疫系统既利用细菌获取金属以增殖的需要，也利用金属的先天毒性。因此，致病菌进化出无数的金属感应、金属获取和金属解毒系统，这些系统代表了关键的毒性决定因素。这些系统为开发急需的新型抗菌药物提供了有吸引力的目标，也为开发营养免疫提供了机会。本项目结合了两个实验室(Cavet-Metalsinbacterialpathogens,Linton-Campylobacterbiology)的专业知识，重点研究空肠C.jejuni的金属处理系统，并研究它们在使该病原体在人类和动物宿主中适应金属压力中的作用。  

候选人应持有(或即将获得)相关领域/学科的最低二等荣誉学位(或同等学位)。有普通分子生物学和细菌学技术经验的申请人可申请。  

对于国际学生，我们还提供一个独特的4年博士课程，让你有机会获得认证的教师证书，同时开展独立的研究项目，涵盖生物、医学和健康科学。  

资金的笔记  

自费学生可申请。这个项目有二级收费。  

平等、多样性和包容是曼彻斯特大学成功的基础，也是我们所有活动的核心。